The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 25, 2014
Filed:
Nov. 01, 2011
Applicants:
Thomas Primiano, Monona, WI (US);
Bey-dih Chang, Madison, WI (US);
Jeremy Heidel, Madison, WI (US);
Inventors:
Assignee:
PeptiMed, Inc., Madison, WI (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 38/02 (2006.01); C07H 21/04 (2006.01);
U.S. Cl.
CPC ...
A61K 38/02 (2013.01);
Abstract
This invention describes a protein nanoparticle system for targeting siRNA or other drugs into tumors. The basis of the protein system is elastin-like peptides that self-assemble once exposed to the nucleic acid of the siRNA. Specific targeting peptides are fused to the core ELP structure by standard genetic engineering techniques. These targeting peptides confer specific binding of the nanoparticle to receptors on the surface of tumor cells and allow for uptake of the nanoparticle into the tumor cells.