The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 25, 2014

Filed:

Nov. 12, 2008
Applicants:

Kenzo Takada, Sapporo, JP;

Kantou Nakajima, Sapporo, JP;

Barbara Kistler, Ingelheim Am Rhein, DE;

John Park, Ingelheim Am Rhein, DE;

Inventors:

Kenzo Takada, Sapporo, JP;

Kantou Nakajima, Sapporo, JP;

Barbara Kistler, Ingelheim Am Rhein, DE;

John Park, Ingelheim Am Rhein, DE;

Assignees:

Evec Inc., Sapporo, JP;

Boehringer Ingelheim International GmbH, Ingelheim am Rhein, DE;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); C12N 5/00 (2006.01); C12N 15/00 (2006.01); C07K 16/22 (2006.01); C07H 21/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

Disclosed herein are anti-hGM-CSF monoclonal antibodies and antigen-binding fragments of such antibodies, with improved neutralizing capacity to hGM-CSF activity. Pharmaceutical compositions comprising such an antibody or antigen-binding fragment are also provided. The present invention is useful for the treatment of various diseases that are associated with aberrant expression of hGM-CSF.


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