The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 25, 2014
Filed:
Aug. 01, 2008
Victoria Smith, Burlingame, CA (US);
Scott Ogg, San Francisco, CA (US);
Peter Van Vlasselaer, Portola Valley, CA (US);
Vivian E. Barry, Foster City, CA (US);
Derek Marshall, Pacifica, CA (US);
Alison Kay Holzer, Redwood City, CA (US);
Hector Rodriguez, Brisbane, CA (US);
Miho Oyasu, San Mateo, CA (US);
Scott Alan Mccauley, Brisbane, CA (US);
Carlos Aurelio Garcia, San Lorenzo, CA (US);
Donna Hiroko Tokuoka Biermann, San Mateo, CA (US);
Victoria Smith, Burlingame, CA (US);
Scott Ogg, San Francisco, CA (US);
Peter Van Vlasselaer, Portola Valley, CA (US);
Vivian E. Barry, Foster City, CA (US);
Derek Marshall, Pacifica, CA (US);
Alison Kay Holzer, Redwood City, CA (US);
Hector Rodriguez, Brisbane, CA (US);
Miho Oyasu, San Mateo, CA (US);
Scott Alan McCauley, Brisbane, CA (US);
Carlos Aurelio Garcia, San Lorenzo, CA (US);
Donna Hiroko Tokuoka Biermann, San Mateo, CA (US);
Gilead Biologics, Inc., Foster City, CA (US);
Abstract
The present disclosure provides methodology and compositions for preventing and treating various diseases associated with abnormal cell proliferation, angiogenesis and fibrosis, by using an inhibitor of processed forms of lysyl oxidase or lysyl oxidase-like proteins, an inhibitor of LOX or LOXL, or a synergistic combination thereof combined with other therapeutic agents. Methods and compositions for diagnosing or monitoring various diseases associated with abnormal cell proliferation, angiogenesis and fibrosis, are also provided. Also provided herein are methods and related compositions, medical devices, systems and kits for preventing or treating various diseases and conditions associated with fibrosis with compositions comprising inhibitors of LOX or LOXL.