The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 18, 2014
Filed:
Oct. 05, 2012
Applicant:
Hoffmann-la Roche Inc., Nutley, NJ (US);
Inventors:
Mirjana Andjelkovic, Basel, CH;
Simona M. Ceccarelli, Basel, CH;
Odile Chomienne, Altkirch, FR;
Patrizio Mattei, Riehen, CH;
Assignee:
Hoffmann-La Roche Inc., Nutley, NJ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/205 (2006.01); A61K 31/381 (2006.01); C07D 333/24 (2006.01); C07C 233/51 (2006.01); C07C 231/12 (2006.01); C07C 235/12 (2006.01); A61P 13/12 (2006.01); A61P 3/04 (2006.01); A61P 9/12 (2006.01); A61P 3/06 (2006.01); A61P 9/04 (2006.01); A61P 9/10 (2006.01); A61P 3/00 (2006.01); A61P 3/10 (2006.01); C07D 333/20 (2006.01);
U.S. Cl.
CPC ...
A61K 31/205 (2013.01); A61K 31/381 (2013.01); C07D 333/20 (2013.01); C07D 333/24 (2013.01); C07C 233/51 (2013.01); C07C 231/12 (2013.01); C07C 235/12 (2013.01);
Abstract
This invention relates to novel 4-trimethylammoniobutyrates of the formula wherein A, R, m and n are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds inhibit carnitine palmitoyl transferase (CPT) activity, in particular CPT2 activity, and can be used as medicaments.