The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 18, 2014
Filed:
Nov. 18, 2010
Prabha N. Ibrahim, Mountain View, CA (US);
Wayne Spevak, Berkeley, CA (US);
Hanna Cho, Oakland, CA (US);
Songyuan Shi, Fremont, CA (US);
Chao Zhang, Moraga, CA (US);
Ying Zhang, Fremont, CA (US);
Prabha N. Ibrahim, Mountain View, CA (US);
Wayne Spevak, Berkeley, CA (US);
Hanna Cho, Oakland, CA (US);
Songyuan Shi, Fremont, CA (US);
Chao Zhang, Moraga, CA (US);
Ying Zhang, Fremont, CA (US);
Plexxikon Inc., Berkeley, CA (US);
Abstract
and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds of Formula (I) or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof are active on at least one Raf protein kinase. In certain aspects and embodiments, the described compounds are active in inhibiting proliferation of a Ras mutant cell line. Also described are methods of use thereof to treat diseases and conditions, including diseases and conditions associated with activity of B-Raf V600E mutant protein kinase, including melanoma, glioma, glioblastoma multiforme, pilocytic astrocytoma, colorectal cancer, thyroid cancer, lung cancer, ovarian cancer, prostate cancer, liver cancer, gallbladder cancer, gastrointestinal stromal tumors, biliary tract cancer, and cholangiocarcinoma. Also described are methods of use thereof to treat diseases and conditions, including diseases and conditions associated with activity of c-Raf-1 protein kinase, including acute pain, chronic pain or polycystic kidney disease.