The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 18, 2014

Filed:

Apr. 20, 2007
Applicants:

Timothy J. Guzi, Chatham, NJ (US);

Kamil Paruch, Garwood, NJ (US);

Michael P. Dwyer, Scotch Plains, NJ (US);

Ronald J. Doll, Convent Station, NJ (US);

Viyyoor M. Girijavallabhan, Parsippany, NJ (US);

Alan Mallams, Hackettstown, NJ (US);

Carmen S. Alvarez, Livingston, NJ (US);

Kartik M. Keertikar, East Windsor, NJ (US);

Jocelyn Rivera, Monmouth Junction, NJ (US);

Tin-yau Chan, Edison, NJ (US);

Vincent S. Madison, Mountain Lakes, NJ (US);

Thierry O. Fischmann, Scotch Plains, NJ (US);

Lawrence W. Dillard, Skillman, NJ (US);

Vinh D. Tran, Fountain Valley, CA (US);

Zhenmin He, Shanghai, CN;

Ray Anthony James, Bensalem, PA (US);

Haengsoon Park, Plainsboro, NJ (US);

Vidyadhar M. Paradkar, Somerville, NJ (US);

Douglas Walsh Hobbs, Yardley, PA (US);

Paul Kirschmeier, Basking Ridge, NJ (US);

Rajat Bannerji, Morristown, NJ (US);

Inventors:

Timothy J. Guzi, Chatham, NJ (US);

Kamil Paruch, Garwood, NJ (US);

Michael P. Dwyer, Scotch Plains, NJ (US);

Ronald J. Doll, Convent Station, NJ (US);

Viyyoor M. Girijavallabhan, Parsippany, NJ (US);

Alan Mallams, Hackettstown, NJ (US);

Carmen S. Alvarez, Livingston, NJ (US);

Kartik M. Keertikar, East Windsor, NJ (US);

Jocelyn Rivera, Monmouth Junction, NJ (US);

Tin-Yau Chan, Edison, NJ (US);

Vincent S. Madison, Mountain Lakes, NJ (US);

Thierry O. Fischmann, Scotch Plains, NJ (US);

Lawrence W. Dillard, Skillman, NJ (US);

Vinh D. Tran, Fountain Valley, CA (US);

Zhenmin He, Shanghai, CN;

Ray Anthony James, Bensalem, PA (US);

Haengsoon Park, Plainsboro, NJ (US);

Vidyadhar M. Paradkar, Somerville, NJ (US);

Douglas Walsh Hobbs, Yardley, PA (US);

Paul Kirschmeier, Basking Ridge, NJ (US);

Rajat Bannerji, Morristown, NJ (US);

Assignees:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Pharmacopeia, LLC, San Diego, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); A61K 31/519 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

In its many embodiments, the present invention provides a method of inhibiting one or more cyclin dependent kinases in a patient comprising administering to said patient a therapeutically effective amount of at least one pyrazolo[1,5-a]pyrimidine compound or a pharmaceutical composition comprising such compound, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions. An example pyrazolo[1,5-a]pyrimidine compound useful in the present invention is shown below:


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