The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 18, 2014

Filed:

Sep. 19, 2013
Applicant:

Merck Patentgesellschaft, Darmstadt, DE;

Inventors:

Andreas Bathe, Darmstadt, DE;

Bernd Helfert, Ober-Ramstadt, DE;

Steffen Neuenfeld, Messel, DE;

Heike Kniel, Heppenheim, DE;

Matthias Bartels, Darmstadt, DE;

Susanne Rudolph, Dieburg, DE;

Henning Bottcher, Darmstadt, DE;

Assignee:

Merck Patentgesellschaft, Darmstadt, DE;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/496 (2006.01); C07D 405/14 (2006.01);
U.S. Cl.
CPC ...
Abstract

The invention relates to new crystalline modifications of the hydrochloride of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine, crystalline modification of the dihydrochloride of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine and amorphous 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine hydrochloride which are suitable in particular for the preparation of solid medicaments for the treatment or prevention of depressive disorders, anxiety disorders, bipolar disorders, mania, dementia, substance-related disorders, sexual dysfunctions, eating disorders, obesity, fibromyalgia, sleeping disorders, psychiatric disorders, cerebral infarct, tension, for the therapy of side-effects in the treatment of hypertension, cerebral disorders, chronic pain, acromegaly, hypogonadism, secondary amenorrhea, premenstrual syndrome and undesired puerperal lactation.


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