The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 18, 2014

Filed:

Nov. 12, 2009
Applicants:

Zhaoning Zhu, Plainsboro, NJ (US);

William J. Greenlee, Teaneck, NJ (US);

Xianhai Huang, Warren, NJ (US);

Jun Qin, Somerset, NJ (US);

Xiaoxiang Liu, River Vale, NJ (US);

Hongmei LI, Warren, NJ (US);

Wei Zhou, Kenilworth, NJ (US);

Anandan Palani, Bridgewater, NJ (US);

Xiaohong Zhu, Edison, NJ (US);

Monica L. Vicarel, Basking Ridge, NJ (US);

Mihirbaran Mandal, Scotch Plains, NJ (US);

Zhong-yue Sun, Parlin, NJ (US);

Chad E. Bennett, Metuchen, NJ (US);

Troy Michael Mccracken, Garwood, NJ (US);

Gioconda V. Gallo, Summit, NJ (US);

Inventors:

Zhaoning Zhu, Plainsboro, NJ (US);

William J. Greenlee, Teaneck, NJ (US);

Xianhai Huang, Warren, NJ (US);

Jun Qin, Somerset, NJ (US);

Xiaoxiang Liu, River Vale, NJ (US);

Hongmei Li, Warren, NJ (US);

Wei Zhou, Kenilworth, NJ (US);

Anandan Palani, Bridgewater, NJ (US);

Xiaohong Zhu, Edison, NJ (US);

Monica L. Vicarel, Basking Ridge, NJ (US);

Mihirbaran Mandal, Scotch Plains, NJ (US);

Zhong-Yue Sun, Parlin, NJ (US);

Chad E. Bennett, Metuchen, NJ (US);

Troy Michael McCracken, Garwood, NJ (US);

Gioconda V. Gallo, Summit, NJ (US);

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 471/04 (2006.01); C07D 498/04 (2006.01); A61K 31/5395 (2006.01);
U.S. Cl.
CPC ...
Abstract

In many embodiments, the present invention provides novel heterocyclic compounds which are modulators of gamma secretase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more disease associated with the central nervous system using such compounds or pharmaceutical compositions.


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