The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 18, 2014
Filed:
Nov. 02, 2007
Jae Ii Kim, Gwangju, KR;
Hye Whon Rhim, Seoul, KR;
Hyun Jeong Kim, Seoul, KR;
Hong Won Suh, Yongin-si, KR;
Soung Hun Roh, Gwangju, KR;
Jung a Yun, Yongin-si, KR;
Seung Kyu Lee, Yeosu-si, KR;
Young Jae Eu, Daejeon, KR;
Heung Sik NA, Seoul, KR;
Jae II Kim, Gwangju, KR;
Hye Whon Rhim, Seoul, KR;
Hyun Jeong Kim, Seoul, KR;
Hong Won Suh, Yongin-si, KR;
Soung Hun Roh, Gwangju, KR;
Jung A Yun, Yongin-si, KR;
Seung Kyu Lee, Yeosu-si, KR;
Young Jae Eu, Daejeon, KR;
Heung Sik Na, Seoul, KR;
Anygen Co., Ltd., Gwangju, KR;
Abstract
The present invention relates to a method for increasing the binding reversibility of a ω-conotoxin to a N-type calcium channel, which comprises preparing a ω-conotoxin having a Ile and/or Ala residue at a position of amino acid (11 and/or 12), respectively in the second loop between cysteine residues (2 and 3) of the ω-conotoxin represented by the formula I, such that the prepared ω-conotoxin has the increased binding reversibility to N-type calcium channel. In addition, the present invention relates to a novel ω-conotoxin and a pharmaceutical composition having plausible properties in view of blocking activity to and specificity to N-type calcium channel, and dramatically improved binding reversibility to N-type calcium channel.