The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 18, 2014
Filed:
May. 27, 2011
Dean M. Scholl, Burlingame, CA (US);
Dana M. Gebhart, San Francisco, CA (US);
Steven R. Williams, San Francisco, CA (US);
Gregory R. Govoni, San Carlos, CA (US);
David W. Martin, Jr., Mill Valley, CA (US);
Dean M. Scholl, Burlingame, CA (US);
Dana M. Gebhart, San Francisco, CA (US);
Steven R. Williams, San Francisco, CA (US);
Gregory R. Govoni, San Carlos, CA (US);
David W. Martin, Jr., Mill Valley, CA (US);
AvidBiotics Corp., South San Francisco, CA (US);
Abstract
This disclosure relates to the discovery and isolation of the entire cluster of genes encoding R-type high molecular weight bacteriocins that specifically killbacteria, dangerous human pathogens. Also disclosed are methods of producing the R-type bacteriocins in innocuous producer cells that, unlike, do not die in the presence of oxygen. Disclosed also is the specific gene of the isolated gene cluster that determines the killing spectrum of the R-type bacteriocin and the demonstration that the killing spectra of diffocins can be altered by engineering orf1374 of the diffocin genetic locus. This invention offers a potent bactericidal agent and a means to make it in order to kill selectivelybacteria in the environment of the gastrointestinal tract where they can cause great harm and even death of the infected patient or farm animal.