The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 18, 2014
Filed:
Jan. 05, 2012
Reginald Brys, Korbeek-Dijle, BE;
Nick Vandeghinste, Koningshooikt, BE;
Peter Herwig Maria Tomme, Gent, BE;
Hubertus Johanus Matheus Klaassen, Herent, BE;
Reginald Brys, Korbeek-Dijle, BE;
Nick Vandeghinste, Koningshooikt, BE;
Peter Herwig Maria Tomme, Gent, BE;
Hubertus Johanus Matheus Klaassen, Herent, BE;
Galapagos N.V., Mechelen, BE;
Abstract
The application discloses methods for identifying and using compounds that inhibit extra-cellular matrix (ECM) degradation and inflammation, using a polypeptide sequence including SEQ ID NO: 17-127 (hereinafter 'TARGETS') and fragments thereof, expression inhibitory agents such as antisense polynucleotide, a ribozyme, and a small interfering RNA (siRNA), comprising a nucleic acid sequence complementary to, or engineered from, a naturally occurring polynucleotide sequence encoding a polypeptide of SEQ ID NO: 17-127, useful in pharmaceutical compositions comprising said agent, for the treatment, or prevention, of chronic joint degenerative and/or inflammatory diseases such as rheumatoid arthritis.
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