The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 11, 2014
Filed:
Mar. 12, 2007
Vasantha P. Rao, Cary, NC (US);
Patrick J. Casey, Chapel Hill, NC (US);
Peifeng Deng, Chapel Hill, NC (US);
Yuri K. Peterson, Durham, NC (US);
Vasantha P. Rao, Cary, NC (US);
Patrick J. Casey, Chapel Hill, NC (US);
Peifeng Deng, Chapel Hill, NC (US);
Yuri K. Peterson, Durham, NC (US);
Duke University, Durham, NC (US);
Abstract
Inhibition of geranylgeranylation of Rho GTPases and heterotrimeric G-proteins in the aqueous outflow pathway increases aqueous humor outflow, possibly through the tissue relaxation, and through altered cell adhesive interactions and actin cytoskeletal organization in cells of the outflow pathway. In addition, such inhibition is useful for treating age-related macular degeneration. The GGTase-I enzyme is a molecular target for lowering increased ocular pressure in glaucoma patients.