The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 11, 2014
Filed:
Aug. 10, 2012
Mary Jessica Hendrix, Evanston, IL (US);
Lynne-marie Postovit, London, CA;
Richard Edward Barnet Seftor, Chicago, IL (US);
Elisabeth Ann Seftor, Chicago, IL (US);
Mary Jessica Hendrix, Evanston, IL (US);
Lynne-Marie Postovit, London, CA;
Richard Edward Barnet Seftor, Chicago, IL (US);
Elisabeth Ann Seftor, Chicago, IL (US);
Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL (US);
Abstract
The invention provides compositions comprising one or more isolated factors from a microenvironment of human embryonic stem cells (hESCs), including, but not limited to, Lefty and inhibitors of Nodal. The invention also provides methods of utilizing factors derived from human embryonic stem cells (hESC) and their microenvironment to treat and prevent tumor formation and progression and to inhibit tumor cell aggressiveness. The invention further provides methods of inhibiting tumor cell growth and/or treating aggressive tumors in a mammal comprising administering to the mammal, having at least one tumor cell present in its body, an effective amount of an inhibitor of Nodal activity.