The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 11, 2014
Filed:
Mar. 31, 2010
Yuichi Hori, Tokyo, JP;
Kazunori Kataoka, Tokyo, JP;
Toshiro Fujita, Tokyo, JP;
Hideki Shimizu, Tokyo, JP;
Shinya Kaname, Tokyo, JP;
Satoru Matsumoto, Tokyo, JP;
Nobuhiro Nishiyama, Tokyo, JP;
Kanjiro Miyata, Tokyo, JP;
Makoto Oba, Tokyo, JP;
Yuichi Hori, Tokyo, JP;
Kazunori Kataoka, Tokyo, JP;
Toshiro Fujita, Tokyo, JP;
Hideki Shimizu, Tokyo, JP;
Shinya Kaname, Tokyo, JP;
Satoru Matsumoto, Tokyo, JP;
Nobuhiro Nishiyama, Tokyo, JP;
Kanjiro Miyata, Tokyo, JP;
Makoto Oba, Tokyo, JP;
The University of Tokyo, Tokyo, JP;
Abstract
Provided are a delivery system that is useful in delivering a double-stranded ribonucleic acid that functions in gene silencing in glomeruli, particularly in mesangial cells and the like, to the tissue or cells, and the like. A polyion complex in the form of a non-polymeric micelle consisting of a double-stranded ribonucleic acid and a block copolymer represented by the formula (I) or (II) below, which are electrostatically bound together, wherein the polyion complex has an average particle diameter of less than 100 nm as measured by a dynamic light scattering measuring method: wherein each symbol is as defined in the specification.