The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 11, 2014
Filed:
Jul. 31, 2009
Edwin Douglas Lephart, Orem, UT (US);
Trent D. Lund, St. Charles, IL (US);
Kenneth David Reginald Setchell, Cincinnati, OH (US);
Robert J. Handa, Phoenix, AZ (US);
Edwin Douglas Lephart, Orem, UT (US);
Trent D. Lund, St. Charles, IL (US);
Kenneth David Reginald Setchell, Cincinnati, OH (US);
Robert J. Handa, Phoenix, AZ (US);
Brigham Young University, Provo, UT (US);
Colorado State University Research Foundation, Fort Collins, CO (US);
Children's Hospital Medical Center, Cincinnati, OH (US);
Abstract
Equol (7-hydroxy-3(4'hydroxyphenyl)-chroman), the major metabolite of the phytoestrogen daidzein, specifically binds and blocks the hormonal action of 5α-dihydrotestosterone (DHT) in vitro and in vivo. Equol can bind circulating free DHT and sequester it from the androgen receptor, thus altering growth and physiological hormone responses that are regulated by androgens. These data suggest a novel model to explain equol's biological properties. The significance of equol's ability to specifically bind and sequester DHT from the androgen receptor have important ramifications in health and disease and may indicate a broad and important usage for equol in the treatment and prevention of androgen-mediated pathologies of skin and hair. Thus, equol can specifically bind DHT and prevent DHT's biological actions in physiological and pathophysiological processes affecting skin and hair.