The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 11, 2014
Filed:
Apr. 26, 2010
Randolf Kerschbaumer, Klosterneuburg, AT;
Friedrich Scheiflinger, Vienna, AT;
Manfred Rieger, Korneuburg, AT;
Michael Thiele, Vienna, AT;
Geert C. Mudde, Breitenfurt, AT;
Juergen Muellberg, Lexington, MA (US);
Rene Hoet, Zeist, NL;
Randolf Kerschbaumer, Klosterneuburg, AT;
Friedrich Scheiflinger, Vienna, AT;
Manfred Rieger, Korneuburg, AT;
Michael Thiele, Vienna, AT;
Geert C. Mudde, Breitenfurt, AT;
Juergen Muellberg, Lexington, MA (US);
Rene Hoet, Zeist, NL;
Baxter International Inc., Deerfield, IL (US);
Baxter Healthcare S.A., Glattpark (Opfikon), CH;
Dyax Corp., Cambridge, MA (US);
Abstract
The present invention relates to monoclonal antibodies and antigen-binding portions thereof that specifically bind to the C-terminal or the center region of macrophage migration inhibitory factor (MIF). These anti-MIF antibodies and antigen-binding portions thereof further inhibit human MIF biological function. The invention also relates to isolated heavy and light chain immunoglobulins derived from anti-MIF antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to a method of identifying anti-MIF antibodies, pharmaceutical compositions comprising these antibodies and a method of using these antibodies and compositions for the treatment of MIF-related conditions.