The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 11, 2014
Filed:
Nov. 02, 2012
Tokyo Metropolitan Organization for Medical Science, Tokyo, JP;
Altif Laboratories, Tokyo, JP;
Hitoshi Sakuraba, Tokyo, JP;
Youichi Tajima, Tokyo, JP;
Mai Ito, Tokyo, JP;
Seiichi Aikawa, Tokyo, JP;
Fumiko Aikawa, Tokyo, JP;
Tokyo Metropolitan Institute of Medical Science, Setagaya-Ku, Tokyo, JP;
Altif Laboratories, Tokyo, JP;
Abstract
The present invention provides, as an enzyme which can be used for enzyme replacement therapy for Fabry disease, a protein having α-galactosidase activity, which shows no allergic adverse side effect, shows a high stability in blood, and can be easily incorporated into a cell of an affected organ. The protein of the present invention is a protein which has acquired α-galactosidase activity by changing the structure of the active site of wild-type human α-N-acetylgalactosaminidase.