The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 04, 2014
Filed:
Mar. 09, 2010
Michael Colin Lawrence, Melbourne, AU;
Brian John Smith, Melbourne, AU;
John Gerbrandt Tasman Menting, Melbourne, AU;
Colin Wesley Ward, Melbourne, AU;
Michael Colin Lawrence, Melbourne, AU;
Brian John Smith, Melbourne, AU;
John Gerbrandt Tasman Menting, Melbourne, AU;
Colin Wesley Ward, Melbourne, AU;
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, AU;
Abstract
The present invention relates generally to structural studies of the insulin binding site of the insulin receptor (IR) and the insulin-like growth factorreceptor (IGF-1R). More particularly, the present invention relates to the crystal structure of the low affinity insulin binding site of the IR ectodomain comprising the C-terminal region of the IR α-chain, as well as the corresponding region of IGF-1R, and to methods of using the crystal and related structural information to screen for and design compounds that interact with or modulate the function of IR and/or IGF-1R.