The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 04, 2014
Filed:
Feb. 20, 2008
Applicants:
Liang Chen, Discovery Bay, CA (US);
Sanjeev Gangwar, Foster City, CA (US);
Vincent Guerlavais, Arlington, MA (US);
Nils Lonberg, Woodside, CA (US);
Qian Zhang, Danville, CA (US);
Inventors:
Liang Chen, Discovery Bay, CA (US);
Sanjeev Gangwar, Foster City, CA (US);
Vincent Guerlavais, Arlington, MA (US);
Nils Lonberg, Woodside, CA (US);
Qian Zhang, Danville, CA (US);
Assignee:
Medarex, LLC, Princeton, NJ (US);
Primary Examiner:
Int. Cl.
CPC ...
C07D 403/00 (2006.01); C07D 209/56 (2006.01); C12N 5/071 (2010.01); A61K 31/497 (2006.01); A61K 31/40 (2006.01);
U.S. Cl.
CPC ...
Abstract
The present disclosure provides drug-ligand conjugates that are potent cytotoxins and include a linker between the drug and ligand where the linker has a single amino acid. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.