The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 04, 2014
Filed:
Oct. 07, 2009
Tim Hugo Maria Jonckers, Edegem, BE;
Wim Bert Griet Schepens, Mechelen, BE;
Geerwin Yvonne Paul Haché, Kapellen, BE;
Beate Sabine Hallenberger, Bromskirchen, DE;
Jennifer Chiyomi Sasaki, Raritan, NJ (US);
Judith Eva Baumeister, Mechelen, BE;
Gerben Albert Van 't Klooster, Breda, NL;
Tim Hugo Maria Jonckers, Edegem, BE;
Wim Bert Griet Schepens, Mechelen, BE;
Geerwin Yvonne Paul Haché, Kapellen, BE;
Beate Sabine Hallenberger, Bromskirchen, DE;
Jennifer Chiyomi Sasaki, Raritan, NJ (US);
Judith Eva Baumeister, Mechelen, BE;
Gerben Albert Van 'T Klooster, Breda, NL;
Janssen R&D Ireland Ltd, Little Island Co, Cork, IE;
Abstract
The present invention relates to compounds of formula (I) that have CYP450 inhibiting properties and are useful as boosting agents when used with HIV treatments. These compounds are represented by formula including the salts and stereoisomeric forms thereof, wherein Ris 5-thiazolyl or 3-pyridinyl; Ris iso-butyl, 2,2-dimethylpropyl; 2-hydroxy-2-methyl-propyl or cyclohexylmethyl; Ris phenyl optionally substituted with one or more halogens, trifluoromethyl, C-alkyl or C-alkoxy wherein optionally two of said alkoxy groups are be linked to each other to form a 5 or 6-membered ring; heteroaryl; Ccycloalkyl optionally substituted with one or more halogens; Calkyl optionally substituted with heteroaryl; —O—CH— (heteroaryl). As boosting agents they are able to increase at least one of the pharmacokinetic variables of certain drugs when co-administered, or improve the bioavailability of certain drugs. Methods for the preparation of the compounds of the invention and pharmaceutical compositions comprising these compounds are also provided.