The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8664389 B1

PDF
Full Text
Expired
Date of Patent:
Mar. 04, 2014

Filed:

Aug. 12, 2009
Applicants:

Ramanadham Jyothi Prasad, Andhra Pradesh, IN;

Bhujanga Rao Adibhatla Kali Satya, Andhra Pradesh, IN;

Nannapaneni Venkaiah Chowdary, Andhra Pradesh, IN;

Inventors:

Ramanadham Jyothi Prasad, Andhra Pradesh, IN;

Bhujanga Rao Adibhatla Kali Satya, Andhra Pradesh, IN;

Nannapaneni Venkaiah Chowdary, Andhra Pradesh, IN;

Assignee:

Natco Pharma Limited, Andhra Pradesh, IN;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 257/12 (2006.01); C07C 251/00 (2006.01); C07D 239/94 (2006.01); C07D 405/04 (2006.01); C07D 407/10 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention relates to an improved and novel process for the preparation of high purity crystalline base of Lapatinib of formula-(1) having chemical name N-{3-chloro-4-[(3-fluorobenzyloxy]phenyl}-6-[5-({[2-(methanesulfonyl)ethyl]amino}methyl]-2-furyl]-4-quin-azolinamine and its pharmaceutically acceptable salts. The present invention further relates to intermediates according to formula (8) and formula (9) used in this process.


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