The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 04, 2014
Filed:
Feb. 26, 2010
Applicants:
Bira Arya, Ellicott City, MD (US);
Vladimir L. Larionov, Potomac, MD (US);
Inventors:
Bira Arya, Ellicott City, MD (US);
Vladimir L. Larionov, Potomac, MD (US);
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); A61K 38/04 (2006.01); A61K 38/08 (2006.01); A61K 38/10 (2006.01); C07K 9/00 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 15/11 (2006.01); C12N 15/63 (2006.01);
U.S. Cl.
CPC ...
Abstract
It is disclosed herein that SPANX-B is uniquely expressed in a number of human tumors and that SPANX-B is an immunogenic antigen that is recognized by human T cells inducing helper CD4and cytolytic CD8T cell responses. Specific SPANX-B polypeptides and polynucleotides are disclosed that can be used to generate an immune response. In several embodiments, these polypeptides can be used for the treatment of a variety of cancers, including melanoma, colon carcinoma, ovarian cancer, breast cancer, myeloma, lung carcinoma and renal cancer.