The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 04, 2014
Filed:
Jun. 08, 2012
Ian Christopher Parsons, Belmont, MA (US);
Jonathan Lansing, Reading, MA (US);
Daniela Becatti, Boston, MA (US);
Scott Bailey, Somerville, MA (US);
Carlos J. Bosques, Arlington, MA (US);
Ian Christopher Parsons, Belmont, MA (US);
Jonathan Lansing, Reading, MA (US);
Daniela Becatti, Boston, MA (US);
Scott Bailey, Somerville, MA (US);
Carlos J. Bosques, Arlington, MA (US);
Momenta Pharmaceuticals, Inc., Cambridge, MA (US);
Abstract
The present disclosure provides nuclear magnetic resonance (NMR) methods for characterizing mixtures of N-linked glycans. Without limitation, methods of the present disclosure may be useful in characterizing monosaccharide composition, branching, fucosylation, sulfation, phosphorylation, sialylation linkages, presence of impurities and/or efficiency of a labeling procedure (e.g., labeling with a fluorophore such as 2-AB). In certain embodiments, the methods can be used quantitatively. In certain embodiments, the methods can be combined with enzymatic digestion to further characterize glycan mixtures.