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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8663653 B1

PDFFull Text
Expired
Date of Patent:
Mar. 04, 2014

Filed:

Jul. 24, 2009

Efficient cell culture system for hepatitis c virus genotype 2b

Applicants:

Judith M. Gottwein, Frederiksberg C, DK;

Maria Lisa Knudsen, Stockholm, DK;

Troels Kasper Høyer Scheel, København NV, DK;

Jens Bukh, Praestø, DK;

Inventors:

Judith M. Gottwein, Frederiksberg C, DK;

Maria Lisa Knudsen, Stockholm, DK;

Troels Kasper Høyer Scheel, København NV, DK;

Jens Bukh, Praestø, DK;

Assignee:

Hvidovre Hospital, Hvidovre, DK;

Attorneys:

Thompson Coburn LLP

Charles P. Romano

Primary Examiner:

Louise Humphrey

Int. Cl.
CPC ...
A61K 39/12 (2006.01); A61K 39/29 (2006.01); C12Q 1/70 (2006.01); C12N 15/00 (2006.01); C12N 5/071 (2010.01); C12N 1/20 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present inventors developed hepatitis C virus 2b/2a intergenotypic recombinants in which the JFH1 structural genes (Core, E1 and E2), p7 and the complete NS2 were replaced by the corresponding genes of the genotype 2b reference strain J8. Sequence analysis of recovered 2b/2a recombinants from 2 transfection experiments revealed that 2b/2a was genetically stable. Conclusion: The developed 2b/2a viruses provide a robust in vitro tool for research in HCV genotype 2b, including vaccine studies and functional analysis.

Find Patent Forward Citations

Gottwein, Judith. (2014). Efficient cell culture system for hepatitis c virus genotype 2b (U.S. Patent No. 8663653). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/8663653

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