The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 25, 2014
Filed:
May. 22, 2009
Xin Shen, Shanghai, CN;
Huaxing Zhan, Shanghai, CN;
Jidong Yang, Shanghai, CN;
Xiao He, Shanghai, CN;
Fuxing Lin, Shanghai, CN;
Shaohong Wu, Shanghai, CN;
Xin Shen, Shanghai, CN;
Huaxing Zhan, Shanghai, CN;
Jidong Yang, Shanghai, CN;
Xiao He, Shanghai, CN;
Fuxing Lin, Shanghai, CN;
Shaohong Wu, Shanghai, CN;
Shanghai Parling Pharma-Tech. Co., Ltd., Shanghai, CN;
Abstract
Described is a process for preparing docetaxel 1, including the following steps: a) hydroxyl acylation reaction of compound 2 and 3 to obtain compound 4; b) deprotection group Rof the hydroxyl group of compound 4 obtained from step a to prepare compound 5; c) removing one tert-butoxycarbonyl of compound 5 obtained from step b to prepare compound 6; d) removing one acetyl of compound 6 obtained from step c to prepare compound 1; wherein, Rrepresents tert-butyl dimethyl silyl, triethylsilyl, ethoxyethyl, tetrahydropyranyl, trichloroethoxycarbonyl or methoxymethyl, Boc is tert-butoxycarbonyl, Ac is acetyl, and Ph is phenyl. Also disclosed are intermediates of docetaxel and methods for preparation thereof.