The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 25, 2014
Filed:
Apr. 09, 2010
Fang Liu, Toronto, CA;
Fang Liu, Toronto, CA;
Centre for Addiction and Mental Health, Toronto, Ontario, CA;
Abstract
The present invention provides compounds, compositions and methods for inhibiting D2R-DISC1 interaction. Specifically, the present invention provides a polypeptide comprising the amino acid sequence KIYIVLRRRRKRVNT (SEQ ID NO: 1) or SEQ ID NO:5, a fragment thereof, or a polypeptide comprising an amino acid sequence that is at least 80% identical to SEQ ID NO: 1 or 5, or a fragment thereof, wherein the polypeptide is not a naturally occurring dopamine receptor. Also provided is a method of identifying an agent that inhibits the interaction of D2R with DISC1, a method of identifying an agent that binds to the polypeptide sequence defined by SEQ ID NO: 1 or 5, and a method of inhibiting D2R interaction with DISC1 in a mammal comprising administering an agent that inhibits the interaction of D2R with DISC1 to the mammal.