The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 25, 2014
Filed:
May. 25, 2012
William Elliott Bay, Ridgefield, CT (US);
Rajesh K. Agarwal, Yorktown Heights, NY (US);
Kiran Chaudhary, West Nyack, NY (US);
Shingai Majuru, Brewster, NY (US);
Michael M. Goldberg, Englewood, NJ (US);
Joanne P. Corvino, Harrison, NY (US);
Moise Azria, Basel, CH;
Joseph Ault, Blairstown, NJ (US);
Simon D. Bateman, Randolph, NJ (US);
Subash Patel, Somerville, NJ (US);
Joseph Sikora, Succasunna, NJ (US);
Rebecca F. Yang, Randolph, NJ (US);
Joseph Zielinski, Florham Park, NJ (US);
William Elliott Bay, Ridgefield, CT (US);
Rajesh K. Agarwal, Yorktown Heights, NY (US);
Kiran Chaudhary, West Nyack, NY (US);
Shingai Majuru, Brewster, NY (US);
Michael M. Goldberg, Englewood, NJ (US);
JoAnne P. Corvino, Harrison, NY (US);
Moise Azria, Basel, CH;
Joseph Ault, Blairstown, NJ (US);
Simon D. Bateman, Randolph, NJ (US);
Subash Patel, Somerville, NJ (US);
Joseph Sikora, Succasunna, NJ (US);
Rebecca F. Yang, Randolph, NJ (US);
Joseph Zielinski, Florham Park, NJ (US);
Emisphere Technologies, Inc., Roseland, NJ (US);
Novartis AG, Basel, CH;
Abstract
The inventors have discovered that the disodium salt of certain delivery agents has surprisingly greater efficacy for delivering active agents than the corresponding monosodium salt. Furthermore, the inventors have discovered that the disodium salts of these delivery agents form solvates with ethanol and hydrates with water. Preferred delivery agents include, but are not limited to, N-(5-chlorosalicyloyl)-8-aminocaprylic acid (5-CNAC), N-(10-[2-hydroxybenzoyl]amino)decanoic acid (SNAD), and sodium N-(8-[2-hydroxybenzoyl]amino)caprylate (SNAC). The invention also provides methods of preparing the disodium salt, ethanol solvate, and hydrate and compositions containing the disodium salt, ethanol solvate, and/or hydrate.