The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 25, 2014
Filed:
Jan. 30, 2009
Lloyd P. Aiello, Belmont, MA (US);
Tamie JO Chilcote, San Francisco, CA (US);
Sukanto Sinha, San Francisco, CA (US);
Edward P. Feener, North Reading, MA (US);
Lloyd P. Aiello, Belmont, MA (US);
Tamie Jo Chilcote, San Francisco, CA (US);
Sukanto Sinha, San Francisco, CA (US);
Edward P. Feener, North Reading, MA (US);
Activesite Pharmaceuticals, Inc., San Francisco, CA (US);
Joslin Diabetes Center, Boston, MA (US);
Abstract
We have identified classes of kallikrein inhibitors as compounds that are useful in the reduction of vascular permeability (e.g., retinal vascular permeability and cerebral vascular permeability) and astrocyte activation. Diseases and conditions associated with increased vascular permeability include diabetic retinopathy, hemorrhagic stroke, and macular edema. Diseases and conditions associated with astrocyte activation include Alzheimer's disease, multiple sclerosis, Parkinson's disease, amyotrophic lateral sclerosis, Creutzfeldt-Jakob disease, stroke, epilepsy, and brain trauma.