The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 25, 2014

Filed:

Aug. 31, 2012
Applicants:

Shaoqing Chen, Bridgewater, NJ (US);

Javier DE Vicente Fidalgo, Foster City, CA (US);

Matthew Michael Hamilton, Hackettstown, NJ (US);

Johannes Cornelius Hermann, Jersey City, NJ (US);

Joshua Kennedy-smith, New York, NY (US);

Hongju LI, Edison, NJ (US);

Allen John Lovey, North Caldwell, NJ (US);

Matthew C. Lucas, Verona, NJ (US);

Kin-chun Thomas Luk, North Caldwell, NJ (US);

Stephen M. Lynch, Westfield, NJ (US);

Counde O'yang, Beijing, CN;

Fernando Padilla, Verona, NJ (US);

Ryan Craig Schoenfeld, Basking Ridge, NJ (US);

Achyutharao Sidduri, Livingston, NJ (US);

Michael Soth, Glen Rock, NJ (US);

Ce Wang, Beijing, CN;

Peter Michael Wovkulich, Nutley, NJ (US);

Xiaohu Zhang, Jiangsu, CN;

Inventors:

Shaoqing Chen, Bridgewater, NJ (US);

Javier de Vicente Fidalgo, Foster City, CA (US);

Matthew Michael Hamilton, Hackettstown, NJ (US);

Johannes Cornelius Hermann, Jersey City, NJ (US);

Joshua Kennedy-Smith, New York, NY (US);

Hongju Li, Edison, NJ (US);

Allen John Lovey, North Caldwell, NJ (US);

Matthew C. Lucas, Verona, NJ (US);

Kin-Chun Thomas Luk, North Caldwell, NJ (US);

Stephen M. Lynch, Westfield, NJ (US);

Counde O'yang, Beijing, CN;

Fernando Padilla, Verona, NJ (US);

Ryan Craig Schoenfeld, Basking Ridge, NJ (US);

Achyutharao Sidduri, Livingston, NJ (US);

Michael Soth, Glen Rock, NJ (US);

Ce Wang, Beijing, CN;

Peter Michael Wovkulich, Nutley, NJ (US);

Xiaohu Zhang, Jiangsu, CN;

Assignee:

Hoffmann-LaRoche Inc., Nutley, NJ (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/495 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.


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