The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 25, 2014
Filed:
Feb. 02, 2007
Eduardo Marban, Beverly Hills, CA (US);
Ronald A. LI, Baltimore, MD (US);
Hee Cheol Cho, Columbia, MD (US);
Suk-ying Tsang, Hong Kong, CN;
Tian Xue, Baltimore, MD (US);
Eduardo Marban, Beverly Hills, CA (US);
Ronald A. Li, Baltimore, MD (US);
Hee Cheol Cho, Columbia, MD (US);
Suk-Ying Tsang, Hong Kong, CN;
Tian Xue, Baltimore, MD (US);
The Johns Hopkins University, Baltimore, MD (US);
Abstract
The present invention relates to novel compositions and methods to induce, and/or modulate bio-electrical rhythms (e.g. in cardiac, neuronal and pancreatic cells) by fine-tuning the activity of HCN-encoded pacemaker channels via a novel protein- and genetic-engineering approach to augment or attenuate the associated physiological responses (e.g. heart beat, neuronal firing, insulin secretion, etc) for achieving various therapeutic purposes (e.g. sick sinus syndrome, epilepsy, neuropathic pain, diabetes, etc).