The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 25, 2014
Filed:
Feb. 17, 2005
Steven J. Demarco, Diegten, CH;
Kerstin Moehle, Wettswil, CH;
Heiko Henze, Zürich, CH;
Odile Sellier, Zürich, CH;
Françoise Jung, Huningue, FR;
Frank Gombert, Huttingen, DE;
Daniel Obrecht, Battwil, CH;
Christian Ludin, Obeswil, CH;
Steven J. DeMarco, Diegten, CH;
Kerstin Moehle, Wettswil, CH;
Heiko Henze, Zürich, CH;
Odile Sellier, Zürich, CH;
Françoise Jung, Huningue, FR;
Frank Gombert, Huttingen, DE;
Daniel Obrecht, Battwil, CH;
Christian Ludin, Obeswil, CH;
Polyphor Ltd, Allschwil, CH;
Universitat Zurich, Zurich, CH;
Abstract
Template-fixed β-hairpin peptidomimetics of the general formulae wherein Z is a chain of 11 α-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly, or Pro, or Pro(4NHCOPhe), or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to inhibit proteases, in particular serine proteases, especially Cathepsin G or Elastase or Tryptase. These β-hairpin peptidomimetics can be manufactured by processes which are based on a mixed solid- and solution phase synthetic strategy.