The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 25, 2014
Filed:
Feb. 08, 2012
David B. Rozema, Middleton, WI (US);
Darren H. Wakefield, Fitchburg, WI (US);
David L. Lewis, Madison, WI (US);
Jason Klein, Madison, WI (US);
SO Wong, Oregon, WI (US);
Jon A. Wolff, Madison, WI (US);
James E. Hagstrom, Middleton, WI (US);
David B. Rozema, Middleton, WI (US);
Darren H. Wakefield, Fitchburg, WI (US);
David L. Lewis, Madison, WI (US);
Jason Klein, Madison, WI (US);
So Wong, Oregon, WI (US);
Jon A. Wolff, Madison, WI (US);
James E. Hagstrom, Middleton, WI (US);
Arrowhead Madison Inc., Madison, WI (US);
Abstract
The present invention is directed to compounds, compositions, and methods useful for delivering polynucleotides or other cell-impermeable molecules to mammalian cells. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery vehicles. The use of multiple reversible or labile linkages connecting component parts provides for physiologically responsive activity modulation.