The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 25, 2014
Filed:
Aug. 14, 2009
Mark A. Miller, Chevy Chase, MD (US);
Rachel Schneerson, Bethesda, MD (US);
Joanna Kubler-kielb, Bethesda, MD (US);
John B. Robbins, New York, NY (US);
Zuzana Biesova, Rockville, MD (US);
Jerry Keith, Olney, MD (US);
Mark A. Miller, Chevy Chase, MD (US);
Rachel Schneerson, Bethesda, MD (US);
Joanna Kubler-Kielb, Bethesda, MD (US);
John B. Robbins, New York, NY (US);
Zuzana Biesova, Rockville, MD (US);
Jerry Keith, Olney, MD (US);
Other;
Abstract
Disclosed are immunogenic conjugates having the general formula:M2e-Cys-S—CH—C(O)—NH—CH—CH2-C(O—)NH-Lys-Pr,were M2e is the influenza M2 ectodomain (M2e) peptide; Cys is a cysteine amino acid residue present in the M2e peptide; S the sulfur present in the cysteine amino acid residue; CH2-CO—NH—CH2-CH2-CO the linking group; NH the amine group present in a lysine residue of the carrier; Lys is a lysine amino acid residue and Pr the carrier protein. Also disclosed are isolated immunogens that include an immunogenic fragment of an influenza HA protein including the polybasic cleavage site, wherein the immunogenic fragment of the influenza HA protein has been modified to remove an N-terminal leader amino acid sequence and a C-terminal transmembrane domain. Also disclosed are methods producing an influenza vaccine specific for an identified influenza strain.