The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 25, 2014
Filed:
Sep. 17, 2009
Maureen D. O'connor-mccourt, Beaconsfield, CA;
Traian Sulea, Kirkland, CA;
John C. Zwaagstra, Chomedey-Laval, CA;
Jason Baardsnes, Montreal, CA;
Catherine Collins, Dorval, CA;
Maureen D. O'Connor-McCourt, Beaconsfield, CA;
Traian Sulea, Kirkland, CA;
John C. Zwaagstra, Chomedey-Laval, CA;
Jason Baardsnes, Montreal, CA;
Catherine Collins, Dorval, CA;
National Research Council of Canada, Ottawa, Ontario, CA;
Abstract
The invention provides hetero-multivalent ligand binging agents (traps) for members of the TGF-β superfamily, as well as methods for making and using such constructs. In an embodiment of the invention there is provided a hetero-multivalent binding agent with affinity for a member of the TGF-β superfamily. The agent comprises the general structure I:(<bd1>-linker1)-[{<bd1>-linker2-<bd2>-linker3-}-(<bd3>)-(linker4-<bd4>)],where bd1, bd2, bd3 and bd4 are polypeptide binding domains having an affinity for different sites on the same member or for different members of the TGF-β superfamily; at least two of bd1, bd2, bd3, and bd4 are different from each other.