The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 18, 2014
Filed:
Oct. 15, 2008
Rogelio Frutos, Sandy Hook, CT (US);
Dhileepkumar Krishnamurthy, Brookfield, CT (US);
Jason Alan Mulder, New Milford, CT (US);
Sonia Rodriguez, New Milford, CT (US);
Chris Hugh Senanayake, Brookfield, CT (US);
Thomas G. Tampone, Southbury, CT (US);
Rogelio Frutos, Sandy Hook, CT (US);
Dhileepkumar Krishnamurthy, Brookfield, CT (US);
Jason Alan Mulder, New Milford, CT (US);
Sonia Rodriguez, New Milford, CT (US);
Chris Hugh Senanayake, Brookfield, CT (US);
Thomas G. Tampone, Southbury, CT (US);
Boehringer Ingelheim International GmbH, Ingelheim am Rhein, DE;
Abstract
The invention relates to improved methods of preparing dihydrothienopyrimidines of formula 1, and intermediates thereof, (I) wherein X is SO or SO, preferably SO, and wherein R, R, R, R, Rand Rhave the meanings given in the description. The methods according to this invention are more suitable for large-scale synthesis of said compounds than prior methods because the new synthetic process avoids distillation and chromatographic purification between steps and results in a higher overall yield of the desired product.