The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 18, 2014
Filed:
Jul. 23, 2009
Guisen Zhang, Xuzhou, CN;
Daopeng Chen, Xuzhou, CN;
Yanqin MA, Xuzhou, CN;
Xiangping Yang, Xuzhou, CN;
Shixia Zhou, Xuzhou, CN;
Liang Chen, Xuzhou, CN;
Guisen Zhang, Xuzhou, CN;
Daopeng Chen, Xuzhou, CN;
Yanqin Ma, Xuzhou, CN;
Xiangping Yang, Xuzhou, CN;
Shixia Zhou, Xuzhou, CN;
Liang Chen, Xuzhou, CN;
NHWA Pharma. Corporation, , CN;
Abstract
A process for the manufacture of agomelatine and its intermediate N-[2-(7-methoxy- 1-naphthy)ethyl]phthalimide is provided and inclues reacting 7-methoxy-1-naphthyl ethanol (III) with benzenesulfonyl chloride to obtain 7-methoxy-1 -naphthylethyl benzene sulfonate (IV), which is reacted with potassium phthalimide to produce N-[2-(7-methoxy-1-naphthy)ethyl]phthalimide (II); and subjecting N-[2-(7-methoxy-1-naphthy)ethyl]phthalimide (II) to alkaline hydrolysis and acetylation, to obtain agomelatine.