The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 18, 2014
Filed:
Mar. 22, 2004
Joachim Elmén, Stockholm, SE;
Claes Wahlestedt, Palm Beach, FL (US);
Zicai Liang, Sundbyberg, SE;
Anders Malling Sørensen, Kobenhavn V, SE;
Henrik Ørum, Vaerlose, DK;
Troels Koch, Copenhagen S, DK;
Joachim Elmén, Stockholm, SE;
Claes Wahlestedt, Palm Beach, FL (US);
Zicai Liang, Sundbyberg, SE;
Anders Malling Sørensen, Kobenhavn V, SE;
Henrik Ørum, Vaerlose, DK;
Troels Koch, Copenhagen S, DK;
Santaris Pharma A/S, Hoersholm, DK;
Abstract
The present invention is directed to novel double-stranded short interfering (siRNA) analogues comprising locked nucleic acid (LNA) monomers. Such compounds induces sequence-specific post-transcriptional gene silencing in many organisms by a process known as RNA interference (RNAi). The compounds disclosed herein has improved properties compared to non-modified siRNAs and may, accordingly, be useful as therapeutic agents, e.g., in the treatment of various cancer forms. More particularly, the present invention is directed to siRNA analogues comprising a sense strand and an antisense strand, wherein each strand comprises 12-35 nucleotides and wherein the siRNA analogues comprise at least one locked nucleic acid (LNA) monomer.