The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 18, 2014
Filed:
May. 25, 2012
Applicants:
Liping Liu, Manassas, VA (US);
Adrian Ion Bot, Beverly Hills, CA (US);
David C. Diamond, West Hills, CA (US);
Inventors:
Liping Liu, Manassas, VA (US);
Adrian Ion Bot, Beverly Hills, CA (US);
David C. Diamond, West Hills, CA (US);
Assignee:
MannKind Corporation, Valencia, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/06 (2006.01); A61K 38/00 (2006.01); A61K 51/00 (2006.01); C07K 2/00 (2006.01); C07K 4/00 (2006.01); C07K 5/00 (2006.01); C07K 7/00 (2006.01); C07K 14/00 (2006.01); C07K 16/00 (2006.01); C07K 17/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
Some embodiments relate to analogs of peptides corresponding to class I MHC-restricted T cell epitopes and methods for their generation. These analogs can contain amino acid substitutions at residues that directly interact with MHC molecules, and can confer improved, modified or useful immunologic properties. Additionally, classes of analogs, in which the various substitutions comprise the non-standard residues norleucine and/or norvaline, are disclosed.