The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 18, 2014
Filed:
Jan. 23, 2009
Applicants:
Claus Oxvig, Viby, DK;
Jakob Hauge Mikkelsen, Aarhus C, DK;
Claus Gyrup Nielsen, Maløv, DK;
Inventors:
Assignee:
Aarhus Universitet, Aarhus C, DK;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
The present invention relates in one embodiment to PAPP-A exosite(s) interactors such as antibodies which bind to a region comprising LNR3 of PAPP-A and efficiently inhibit proteolysis of IGFBP-4, but not -5. The region comprising LNR3 represents a substrate binding exosite, which can be targeted for selective proteolytic inhibition. Accordingly, the present invention relates in one embodiment to differential inhibition of natural protease substrates by exosite targeting.