The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 18, 2014
Filed:
Sep. 12, 2008
Applicants:
Leonard Guarente, Chestnut Hill, MA (US);
Shin-ichiro Imai, Somerville, MA (US);
Christopher Armstrong, Cambridge, MA (US);
Inventors:
Leonard Guarente, Chestnut Hill, MA (US);
Shin-ichiro Imai, Somerville, MA (US);
Christopher Armstrong, Cambridge, MA (US);
Assignee:
Massachusetts Institute of Technology, Cambridge, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/02 (2006.01); C12N 9/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
Methods of NAD-dependent of at least one lysine residue in an acetylated protein are disclosed. The methods include combining the acetylated protein with an isolated Sir2 protein or fragment that includes a core domain of the Sir2 protein. The Sir2 protein or fragment of the Sir2 protein can include a human Sir2 protein or a fragment of a human Sir2 protein.