The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 18, 2014
Filed:
Mar. 21, 2008
Allen J. Ebens, Jr., San Carlos, CA (US);
Frederic S. Jacobson, Berkeley, CA (US);
Paul Polakis, Burlingame, CA (US);
Mark X. Sliwkowski, San Carlos, CA (US);
Susan D. Spencer, Tiburon, CA (US);
Allen J. Ebens, Jr., San Carlos, CA (US);
Frederic S. Jacobson, Berkeley, CA (US);
Paul Polakis, Burlingame, CA (US);
Ralph H. Schwall, Pacifica, CA (US);
Mark X. Sliwkowski, San Carlos, CA (US);
Susan D. Spencer, Tiburon, CA (US);
Genentech, Inc., South San Francisco, CA (US);
Abstract
The present invention relates to antibody-drug conjugate compounds of Formula I:Ab-(L-D)  Iwhere one or more maytansinoid drug moieties (D) are covalently linked by L to an antibody (Ab) which binds to an ErbB receptor, or which binds to one or more tumor-associated antigens or cell-surface receptors. These compounds may be used in methods of diagnosis or treatment of cancer, and other diseases and disorders.