The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 18, 2014

Filed:

Aug. 03, 2007
Applicants:

Vernon Michael Holers, Denver, CO (US);

Joshua M. Thurman, Greenwood Village, CO (US);

Christian Taube, Frankfurt, DE;

Erwin W. Gelfand, Englewood, CO (US);

Gary Steven Gilkeson, Charleston, SC (US);

Inventors:

Vernon Michael Holers, Denver, CO (US);

Joshua M. Thurman, Greenwood Village, CO (US);

Christian Taube, Frankfurt, DE;

Erwin W. Gelfand, Englewood, CO (US);

Gary Steven Gilkeson, Charleston, SC (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
Abstract

Disclosed are novel inhibitors of the alternative complement pathway and particularly, novel anti-factor B antibodies. Also disclosed is the use of such inhibitors to reduce or prevent airway hyperresponsiveness and/or airway inflammation by selectively inhibiting the alternative complement pathway, thereby treating diseases in which such conditions play a role. Also disclosed is the use of such inhibitors to reduce or prevent other diseases and conditions, including ischemia-reperfusion injury, by inhibition of the alternative complement pathway.


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