The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 18, 2014
Filed:
Feb. 13, 2012
Vanessa Hsei, San Jose, CA (US);
Iphigenia Koumenis, Winston-Salem, NC (US);
Steven Leong, Berkeley, CA (US);
Zahra Shahrokh, San Francisco, CA (US);
Gerardo Zapata, Berwyn, PA (US);
Vanessa Hsei, San Jose, CA (US);
Iphigenia Koumenis, Winston-Salem, NC (US);
Steven Leong, Berkeley, CA (US);
Zahra Shahrokh, San Francisco, CA (US);
Gerardo Zapata, Berwyn, PA (US);
Genentech, Inc., South San Francisco, CA (US);
Abstract
Described are conjugates formed by an antibody fragment covalently attached to a nonproteinaceous polymer, wherein the apparent size of the conjugate is at least about 500 kD. The conjugates exhibit substantially improved half-life, mean residence time, and/or clearance rate in circulation as compared to the underivatized parental antibody fragment. Also described are conjugates directed against human vascular endothelial growth factor (VEGF), human p185 receptor-like tyrosine kinase (HER2), human CD20, human CD18, human CD11a, human IgE, human apoptosis receptor-2 (Apo-2), human tumor necrosis factor-α (TNF-α), human tissue factor (TF), human αβintegrin, human GPIIb-IIIa integrin, human epidermal growth factor receptor (EGFR), human CD3, and human interleukin-2 receptor α-chain (TAC) for diagnostic and therapeutic applications.