The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 18, 2014
Filed:
Nov. 03, 2009
David Piwnica-worms, Ladue, MO (US);
Shimon Gross, St. Yavne, IL (US);
Vijay Sharma, Wildwood, MO (US);
Seth Gammon, St. Louis, MO (US);
David Piwnica-Worms, Ladue, MO (US);
Shimon Gross, St. Yavne, IL (US);
Vijay Sharma, Wildwood, MO (US);
Seth Gammon, St. Louis, MO (US);
Washington University, Saint Louis, MO (US);
Abstract
Methods of imaging distribution of myeloperoxidase activity in a subject are disclosed. These methods include the use of bioluminescent substrates, including luminol and wavelength-shifted analogues of luminol. Bioluminescent myeloperoxidase substrates that emit light at longer wavelengths compared to luminol are shown to be useful for imaging myeloperoxidase activity in vivo. The disclosed methods can be used for imaging sites of inflammation and other pathological conditions associated with abnormal levels of MPO activity in vivo. Methods of synthesis of luminol analogues are also disclosed.