The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 04, 2014
Filed:
Feb. 26, 2010
Julie Kan, San Diego, CA (US);
Salam A. Shaaban, Boston, MA (US);
Joseph S. Krueger, Boulder, CO (US);
Maryland Franklin, Boulder, CO (US);
Robert C. Wild, Boulder, CO (US);
Julie Kan, San Diego, CA (US);
Salam A. Shaaban, Boston, MA (US);
Joseph S. Krueger, Boulder, CO (US);
Maryland Franklin, Boulder, CO (US);
Robert C. Wild, Boulder, CO (US);
OSI Pharmaceuticals, LLC, Farmingdale, NY (US);
Abstract
The present invention provides tumor cell preparations for use as models of the EMT process for use in the identification of anti-cancer agents, wherein said tumor cell preparations comprise cells of the epithelial tumor cell line CFPAC-1, which are stimulated by receptor ligands to induce EMT, or which have been engineered to inducibly express a protein that stimulates EMT. The present invention also provides methods of identifying potential anti-cancer agents by using such tumor cell preparations to identify agents that inhibit EMT, stimulate MET, or inhibit the growth of mesenchymal-like cells. Such agents should be particularly useful when used in conjunction with other anti-cancer drugs such as EGFR and IGF-1R kinase inhibitors, which appear to be less effective at inhibiting tumor cells that have undergone an EMT.