The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 04, 2014
Filed:
Jun. 30, 2009
Agnieszka B. Sierzchala, Boulder, CO (US);
Douglas J Dellinger, Boulder, CO (US);
Victor R Mokler, Golden, CO (US);
Zoltan Timar, Boulder, CO (US);
Agnieszka B. Sierzchala, Boulder, CO (US);
Douglas J Dellinger, Boulder, CO (US);
Victor R Mokler, Golden, CO (US);
Zoltan Timar, Boulder, CO (US);
Agilent Technologies, Inc., Santa Clara, CA (US);
Abstract
A method and compositions for sulfurizing at least one phosphite or thiophosphite linkage in an oligonucleotide. The methods employ a phenylacetyl disulfide reagent (known as PADS), phenylthioacetic acid (PTAA) in the presence or absence or N-alkyl imidazole in industrially preferred solvents or solvents that are derived from renewable resources. The use of PTAA eliminates the need to 'age' the PADS solution prior to its use in sulfurization reactions.