The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 04, 2014

Filed:

Jul. 29, 2011
Applicants:

Toshio Nakamura, Toshima-ku, JP;

Kazunari Sakagami, Toshima-ku, JP;

Kazuhide Konishi, Toshima-ku, JP;

Kanako Yamamoto, Toshima-ku, JP;

Seiji Masuda, Toshima-ku, JP;

Yohei Matsuda, Toshima-ku, JP;

Kumiko Okada, Toshima-ku, JP;

Tsuyoshi Shibata, Toshima-ku, JP;

Hiroshi Ohta, Toshima-ku, JP;

Akito Yasuhara, Toshima-ku, JP;

Hiroshi Kawamoto, Toshima-ku, JP;

Inventors:

Toshio Nakamura, Toshima-ku, JP;

Kazunari Sakagami, Toshima-ku, JP;

Kazuhide Konishi, Toshima-ku, JP;

Kanako Yamamoto, Toshima-ku, JP;

Seiji Masuda, Toshima-ku, JP;

Yohei Matsuda, Toshima-ku, JP;

Kumiko Okada, Toshima-ku, JP;

Tsuyoshi Shibata, Toshima-ku, JP;

Hiroshi Ohta, Toshima-ku, JP;

Akito Yasuhara, Toshima-ku, JP;

Hiroshi Kawamoto, Toshima-ku, JP;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4439 (2006.01); A61K 31/415 (2006.01); C07D 231/12 (2006.01); C07D 231/20 (2006.01); C07D 231/38 (2006.01); C07D 403/06 (2006.01); C07D 401/06 (2006.01);
U.S. Cl.
CPC ...
Abstract

Provided is a novel compound represented by formula [I] or a pharmaceutically acceptable salt thereof having antagonistic activity against group II metabolism-type glutamic acid (m-Glu) receptors. The compound or pharmaceutically acceptable salt thereof is useful as a prophylactic or therapeutic agent for diseases such as new mood disorders (depressive and bipolar disorders), anxiety disorders (generalized anxiety disorder, panic disorder, obsessive-compulsive disorder, social anxiety disorder, post-traumatic stress disorder, specific phobias, and acute stress disorder), schizophrenia, Alzheimer's disease, cognitive dysfunction, dementia, drug dependence, convulsions, tremors, pain, sleep disorders, and the like.


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