The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 04, 2014
Filed:
Apr. 15, 2010
Andrew Peter Thomas, Macclesfield, GB;
Elaine Sophie Elizabeth Stokes, Macclesfield, GB;
Laurent Francois Andre Hennequin, Reims Cedex, FR;
Andrew Peter Thomas, Macclesfield, GB;
Elaine Sophie Elizabeth Stokes, Macclesfield, GB;
Laurent Francois Andre Hennequin, Reims Cedex, FR;
AstraZeneca AB, Södertälje, SE;
Abstract
The invention relates to quinazoline derivatives of formula (I), wherein m is an integer from 1 to 3; Rrepresents halogeno or Calkyl; Xrepresents —O—; Ris selected from one of the following three groups: 1) C-5alkylR(wherein Ris piperidinyl-4-yl which may bear one or two substituents selected from hydroxy, halogeno, Calkyl, Chydroxyalkyl and Calkoxy; 2) CalkenylR(wherein Ris as defined hereinbefore); 3) CalkynylR(wherein Ris as defined hereinbefore); and wherein any alkyl, alkenyl or alkynyl group may bear one or more substituents selected from hydroxy, halogeno and amino; and salts thereof; processes for their preparation, pharmaceutical compositions containing a compound of formula (I) or a pharmaceutically acceptable salt thereof as active ingredient. The compounds of formula (I) and the pharmaceutically acceptable salts thereof inhibit the effects of VEGF, a property of value in the treatment of a number of disease states including cancer and rheumatoid arthritis.