The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 04, 2014
Filed:
Dec. 13, 2000
Applicants:
Leonard Guarente, Chestnut Hill, MA (US);
Shin-ichiro Imai, St. Louis, MO (US);
Christopher Armstrong, Jamaica Plain, MA (US);
Inventors:
Leonard Guarente, Chestnut Hill, MA (US);
Shin-Ichiro Imai, St. Louis, MO (US);
Christopher Armstrong, Jamaica Plain, MA (US);
Assignee:
Massachusetts Institute of Technology, Cambridge, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/02 (2006.01); C12N 9/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
Methods of identifying agents which alter the NAD-dependent deacetylation activity of a Sir2 protein or a fragment of a Sir2 protein are disclosed. The acetylated protein can be a nuclear protein, such as a histone protein, or a cytoplasmic protein. The Sir2 protein employed in the methods can include at least a core domain of a Sir2 protein, such as a human Sir2 protein.