The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 28, 2014
Filed:
Mar. 09, 2012
Chitra Mandal, Kolkatta, IN;
Bikas Chandra Pal, Kolkatta, IN;
Kaushik Bhattacharya, Kolkatta, IN;
Suman Kumar Samanta, Kolkatta, IN;
Sayantani Sarkar, Kolkatta, IN;
Ranjita Das, Kolkatta, IN;
Chitra Mandal, Kolkatta, IN;
Bikas Chandra Pal, Kolkatta, IN;
Kaushik Bhattacharya, Kolkatta, IN;
Suman Kumar Samanta, Kolkatta, IN;
Sayantani Sarkar, Kolkatta, IN;
Ranjita Das, Kolkatta, IN;
Council of Scientific and Industrial Research, New Delhi, IN;
Abstract
The present invention relates to two main components, mahanine and mahanimbine (dehydroxy-mahanine) fromfor the treatment of glioblastoma and cervical carcinoma. Mahanimbine exhibited anti-cancer activity against lymphoid leukemia, myeloid leukemia, glioma, cervical carcinoma, pancreatic, colon and lung cancers in nineteen cells of different genetic status. C-3 hydroxy and NH groups are responsible contributing groups for their cytotoxicity. Mahanine reduced the doses of cisplatin and paclitaxel in cervical cancer showing better efficacy and useful as an adjunct chemotherapeutic agent to reduce toxicity these two drugs. A new cheap process for this preparation was established. EtOAc extract containing alkaloids enriched with mahanimbine and mahanine, is active against glioma and cervical cancers. Mahanine is targeting the chaperone Hsp90 which led to the proteasome-dependent degradation of several Hsp90-client proteins in diverse carcinoma types, glioblastoma, cervical carcinoma and pancreatic adenocarcinoma irrespective of their tissue origins thereby killing the cancer cells.